Arthritis
Clinical research
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2024: On the dosing of CBD for osteoarthritis
Cannabinoids dosing for osteoarthritis
https://pubmed.ncbi.nlm.nih.gov/38322713/
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2024: In people with arthritis, a survey reported cannabis use decreased pain with improvements in stiffness, fatigue & swelling
Patient-Reported Outcomes of Pain, Stiffness, and Fatigue Reduction in Rheumatoid and Psoriatic Arthritis With Cannabinoid Use
https://assets.cureus.com/uploads/original_article/pdf/204984/20241025-737028-e9vf8x.pdf
2024: For inflammatory arthritis, an analysis from the UK Medical Cannabis Registry showed the initiation of medical cannabis to reduce pain & anxiety as well as improving sleep
Assessment of clinical outcomes in patients with inflammatory arthritis: analysis from the UK Medical Cannabis Registry
https://pubmed.ncbi.nlm.nih.gov/38976497/
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2024: For people with osteoarthritis in the UK Medical Cannabis Registry, cannabis-based medicines reduced their pain severity, the interference of pain with their life, anxiety levels, sleep quality
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
https://pubmed.ncbi.nlm.nih.gov/38669060/
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2024: In people with osteoarthritis of the hand, a CBD transdermal reduced pain, increased grip strength & improved fatigue, stiffness & anxiety
An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis
https://pubmed.ncbi.nlm.nih.gov/38783008/
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2023: In a survey of people with arthritic joint pain, CBD caused high rates of symptomatic relief & reductions in pharmacological treatments
An Exploratory Cross-Sectional Analysis of Cannabidiol use for Arthritic Joint Pain
https://ccorc.mmjoutcomes.org/wp-content/uploads/2023/10/Nicholas-Frane-CBD-Survey-Poster.pdf
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2023: In a survey of rheumatology patients, they reported a significant reduction in average pain & stiffness via cannabis
POS1573-PARE Patient-Reported Outcome Measures of Pain Alleviation With Cannabinoid Usage in Rheumatoid and Psoriatic Arthritis: a Cross-Sectional Study
https://ard.bmj.com/content/81/Suppl_1/1132.3.abstract
2023: An analysis of public health data finds that people with chronic health conditions are more likely to use cannabis, especially those with arthritis, cancer, HIV, COPD & depression
Associations between adult cannabis use and chronic health conditions in a nationally representative sample of the United States
https://www.tandfonline.com/doi/abs/10.1080/14659891.2023.2288838
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2022: In Australian patients with arthritis, the use of CBD/THC & CBD-only products significantly reduced pain intensity
Medicinal cannabis for Australian patients with chronic refractory pain including arthritis
https://pubmed.ncbi.nlm.nih.gov/37057257/
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2022: In a survey of rheumatoid & psoriatic arthritis patients, medical cannabis gave them significant relief from short & long-term pain as well as reduced stiffness – and for some patients, total pain relief
PARE Patient-Reported Outcome Measures of Pain Alleviation With Cannabinoid Usage in Rheumatoid and Psoriatic Arthritis: a Cross-Sectional Study
https://ard.bmj.com/content/81/Suppl_1/1132.3.abstract
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2022: A survey found for people with arthritis & joint pain, they said CBD helped with pain, physical function & sleep as well as a reduction in other medications
Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study
https://pubmed.ncbi.nlm.nih.gov/35999581
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2022: In patients with arthritis of the thumb, two weeks of topical CBD treatment caused significant improvements in their pain measures
A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis
https://pubmed.ncbi.nlm.nih.gov/35637038
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2022: In humans with osteoarthritis, the use of medical cannabis reduced prescriptions for opioids
Medical Cannabis Use Reduces Opioid Prescriptions in Patients With Osteoarthritis
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2022: In patients with arthritis of the thumb, many of them found topical & oral cannabis helpful
Assessment of Medical Cannabis in Patients With Osteoarthritis of the Thumb Basal Joint
https://pubmed.ncbi.nlm.nih.gov/34893392/
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2006: In the first trial of cannabinoids for arthritis, five weeks of Sativex (1:1 THC:CBD spray) improved pain on movement, pain at rest & quality of life with no serious adverse effects
Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
https://pubmed.ncbi.nlm.nih.gov/16282192/
Best reviews
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2024: For osteoarthritis, a review of the evidence of cannabis for pain & function
Medical cannabis and its efficacy/effectiveness on the management of osteoarthritis pain and function
https://pubmed.ncbi.nlm.nih.gov/38832841/
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2023: A review of cannabis for rheumatoid arthritis (nice chart)
Cannabis and Rheumatoid Arthritis: A Scoping Review Evaluating the Benefits, Risks, and Future Research Directions
https://pubmed.ncbi.nlm.nih.gov/37917863/
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2022: A practical guide to using the cannabinoids in rheumatology (joint pain & arthritis)
Cannabinoids in the rheumatic diseases
https://ouci.dntb.gov.ua/en/works/9jmEezpl/
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2021: This review of 16 studies looks at treating osteoarthritis with CBD
Efficacy of Cannabidiol in Treating Osteoarthritis
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2020: This meta-review rounds up why the endocannabinoid system is being targeted for treating rheumatoid arthritis
The endocannabinoid signaling pathway as an emerging target in pharmacotherapy, earmarking mitigation of destructive events in rheumatoid arthritis
https://www.sciencedirect.com/science/article/abs/pii/S0024320520308602
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Timeline of research
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2024: In a mouse model of knee osteoarthritis, THC helped with pain & disease modification
ORAL GAVAGE OF DELTA-9-TETRAHYDROCANNABINOL PROVIDES PAIN AND DISEASE MODIFICATION IN MOUSE MODELS OF KNEE OSTEOARTHRITIS
https://www.oarsijournal.com/article/S1063-4584(24)00103-1/abstract
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2024: In a rat model of arthritis, CBG improved clinical scores & reduced the genetic expression of pro-inflammatory cytokines
CANNABIGEROL IN THE TREATMENT OF COLLAGEN-INDUCED ARTHRITIS
https://ard.bmj.com/content/83/Suppl_1/722.2
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2024: In a mouse model of arthritis, delta-8 THC reduced inflammation, protected from cartilage & bone erosion & decreased depression-related behaviors
The minor phytocannabinoid delta-8-tetrahydrocannabinol attenuates collagen-induced arthritic inflammation and pain-depressed behaviors
https://pubmed.ncbi.nlm.nih.gov/38834355/
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2024: In a rat model of osteoarthritis, the lesser-known cannabinoid cannabiorcol lowered inflammation & osteoarthritis symptoms
Cannabiorcol as a novel inhibitor of the p38/MSK-1/NF-κB signaling pathway, reducing matrix metalloproteinases in osteoarthritis
https://www.sciencedirect.com/science/article/pii/S0944711324007980
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2023: In a mouse model, the anti-arthritic & anti-inflammatory effects of cannabis essential oil
Antiarthritic and Anti-Inflammatory Properties of Cannabis sativa Essential Oil in an Animal Model
https://pubmed.ncbi.nlm.nih.gov/38256854/
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2023: In a mouse model of osteoarthritis, CBD oil & CBG oil lowered pain & inflammation & helped to protect their local motor activity while the CBG oil reduced cartilage degeneration
Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis
https://pubmed.ncbi.nlm.nih.gov/35994012/
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2023: In a mouse model of arthritis, CBD & CBC produce greater anti-inflammatory effects when working together
The Mechanism of Cannabichromene and Cannabidiol Alone Versus in Combination in the Alleviation of Arthritis-Related Inflammation
https://pubmed.ncbi.nlm.nih.gov/37332213/
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2023: In two mouse models & tissue samples of osteoarthritis, THC reduced cartilage degeneration, pain response & knee inflammation
OP0200 ORAL DELIVERY OF DELTA-9-TETRAHYDROCANNABINOL PROVIDES SYMPTOM AND DISEASE MODIFICATION USING TWO MODELS OF KNEE OSTEOARTHRITIS
https://ard.bmj.com/content/82/Suppl_1/132
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2023: In a rat model of osteoarthritis, CBD inhibited inflammation, lowered pain & reduces pathological changes
Cannabidiol inhibits inflammation in rat osteoarthritis
https://europepmc.org/article/ppr/ppr641884
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2023: An analysis of the pathways used by the cannabinoids to help with rheumatoid arthritis
The Abundant Phytocannabinoids in Rheumatoid Arthritis: Therapeutic Targets and Molecular Processes Identified Using Integrated Bioinformatics and Network Pharmacology
https://pubmed.ncbi.nlm.nih.gov/36983855/
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2023: In osteoarthritis of the knee, hempseed oil & cannabis terpenes helped with improving joint pain & function
Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study
https://pubmed.ncbi.nlm.nih.gov/36837393/
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2023: In a cellular model of rheumatoid arthritis, CBG lowered inflammation via the TRPA1 receptors
Anti-Inflammatory Effects of Cannabigerol in Rheumatoid Arthritis Synovial Fibroblasts and Peripheral Blood Mononuclear Cell Cultures Are Partly Mediated by TRPA1
https://pubmed.ncbi.nlm.nih.gov/36614296
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2022: In a mouse model of hemophilia, PEA helped with pain & the symptoms of arthritis such as joint inflammation
Palmitoylethanolamide Attenuates Pain-like Behavior in Factor VIII Deficient Mice
https://ashpublications.org/blood/article/140/Supplement%201/5578/492940
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2022: In a rat model of rheumatic arthritis, a nano-CBD water caused an improvement in their clinical symptoms
Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis
https://pubmed.ncbi.nlm.nih.gov/36342775
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2022: In an animal model of osteoarthritis, oral THC reduced joint pain & degeneration
ELUCIDATING DISEASE-MODIFYING MECHANISMS OF DELTA-9-TETRAHYDROCANNABINOL IN PRE-CLINICAL OSTEOARTHRITIS
https://www.oarsijournal.com/article/S1063-4584(22)00517-9/fulltext
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2022: In a rat model of arthritis, the terpene myrcene reduced pain transmission as well as inflammation
Anti-Inflammatory and Analgesic Properties of the Cannabis Terpene Myrcene in Rat Adjuvant Monoarthritis
https://pubmed.ncbi.nlm.nih.gov/35887239
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2022: In a mouse model of osteoarthritis, both CBD oil & CBG oil helped with pain & inflammation as well as improved gait & locomotion
Distinctive Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis
https://pubmed.ncbi.nlm.nih.gov/35994012
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2021: In rats, CBD combined with bioflavonoids seems a strong combination for treating osteoarthritis
Antinociceptive and Anti-Inflammatory Properties of Cannabidiol Alone and in Combination with Standardized Bioflavonoid Composition
https://pubmed.ncbi.nlm.nih.gov/33570460/
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2021: In a rat model of osteoarthritis, PEA reduced knee joint swelling, cartilage degradation & inflammatory markers
Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats
https://pubmed.ncbi.nlm.nih.gov/34468900/
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2021: A computational approach helped explain the mechanisms by which CBD would be helpful for osteoarthritis
Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis: Role of Transient Receptor Potential Channels
https://www.mdpi.com/1424-8247/14/10/964
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2021: In an animal model of osteoarthritis, β-caryophyllene both helped with the pain & reduced cartilage degeneration
Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development
https://pubmed.ncbi.nlm.nih.gov/34856202/
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2021: In rats, CBD combined with bioflavonoids seems a strong combination for treating osteoarthritis
Antinociceptive and Anti-Inflammatory Properties of Cannabidiol Alone and in Combination with Standardized Bioflavonoid Composition
https://pubmed.ncbi.nlm.nih.gov/33570460/
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2020: In cells, THCA (the acidic precursor to THC) alleviates arthritis via the CB1 receptor & the nuclear receptor PPARγ
Δ9-TETRAHYDROCANNABINOLIC ACID ALLEVIATES COLLAGEN-INDUCED ARTHRITIS: ROLE OF PPARγ AND CB 1 RECEPTORS
https://pubmed.ncbi.nlm.nih.gov/32510591/
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2019: In mice with arthritis, β-Caryophyllene activates CB2 and PPAR-γ to reduce pain
β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors
https://pubmed.ncbi.nlm.nih.gov/31370242/
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2017: Using CBD early in rats helped prevent the pain and damage of arthritis
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/
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2016: CBD pain patches for rats with arthritis
Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/
2015: In a tissue model of rheumatoid arthritis, the endocannabinoids anandamide, PEA & oleylethanolamine caused anti-inflammatory effects via TRPV1 & TRPA1 in a COX-2-dependent fashion
Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner
https://pubmed.ncbi.nlm.nih.gov/26567045/
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