Endometriosis
Clinical research
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2024: In a survey of people with endometriosis, the cannabis users rated it as “the most effective self-management strategy to reduce symptom intensity” with 90% reducing their pain medication levels
Cannabis use in endometriosis: the patients have their say-an online survey for German-speaking countries
https://pubmed.ncbi.nlm.nih.gov/39162801/
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2024: In a survey of women with endometriosis, cannabis was widely used for their chronic pain
Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain among Women with Endometriosis
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2022: A survey of women with endometriosis finds that the majority report cannabis helpful & many are able to replace other drugs with it
Cannabis use for endometriosis : clinical and legal challenges in Australia and New Zealand
https://researchdirect.westernsydney.edu.au/islandora/object/uws:62139/
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2022: Among women with endometriosis, cannabis consumption for symptom relief during the pandemic was common
Endometriosis and Cannabis Consumption During the COVID-19 Pandemic: An International Cross-Sectional Survey
https://pubmed.ncbi.nlm.nih.gov/35089093
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2022: This study of women with endometriosis looked at how their endocannabinoid levels were related to their pain & disease state
Association of endocannabinoids with pain in endometriosis
https://pubmed.ncbi.nlm.nih.gov/34001768/
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2021: In a survey of women with endometriosis, the majority reported cannabis use for pain relief & sleep & they found their symptom improvement was “much better” for pain sleep, nausea & vomiting with over three-quarters reducing their normal medication usage
Illicit Cannabis Usage as a Management Strategy in New Zealand Women with Endometriosis: An Online Survey
https://pubmed.ncbi.nlm.nih.gov/33275491/
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2021: A retrospective study in humans with endometriosis-associated pelvic pain found medical cannabis helpful for pain & GI symptoms
Effects of cannabis ingestion on endometriosis-associated pelvic pain and related symptoms
https://pubmed.ncbi.nlm.nih.gov/34699540/
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2021: In human females, this study looked at the dysregulation of the endocannabinoid system in endometriosis
Implications of dysregulated endogenous cannabinoid family members in the pathophysiology of endometriosis
https://www.sciencedirect.com/science/article/abs/pii/S2666335X21000707
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2020: In a survey of women with endometriosis, those using cannabis reported high levels of pain reduction & more than half also reduced pharmaceutical medications as well as help for sleep, nausea & vomiting
Cannabis Use, a Self-Management Strategy Among Australian Women With Endometriosis: Results From a National Online Survey
https://pubmed.ncbi.nlm.nih.gov/31722852
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2019: In a survey of people with endometriosis, the majority reported cannabis to be very or moderately effective with over half saying the same about CBD
Self-Reported Efficacy of Cannabis for Endometriosis Pain
https://www.sciencedirect.com/science/article/pii/S1553465019310921
Chart gallery
2022 Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
2023 Cannabis and Endometriosis The Roles of the Gut Microbiota and the Endocannabinoid System
2023 Cannabis and Endometriosis The Roles of the Gut Microbiota and the Endocannabinoid System
2022 Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
Best reviews
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2024: For endometriosis, a review of surveys on the benefits of CBD
Endometriosis: cannabidiol therapy for symptom relief
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(24)00215-3
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2024: A review of eight papers on cannabis for endometriosis-related pain
Evaluating the Current Evidence for the Efficacy of Cannabis in Symptom Management of Endometriosis-Associated Pain
https://pubmed.ncbi.nlm.nih.gov/39211562/
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2024: For endometriosis, review of using CBD to suppress inflammation as well as the associated angiogenesis (formation of new blood vessels)
Cannabidiol as a possible treatment for endometriosis through suppression of inflammation and angiogenesis
https://pubmed.ncbi.nlm.nih.gov/39110084/
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2023: A review of the little known on the interplay between cannabis, endometriosis & the gut microbiome
Cannabis and Endometriosis: The Roles of the Gut Microbiota and the Endocannabinoid System
https://pubmed.ncbi.nlm.nih.gov/38002684/
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2023: A review of using cannabinoids for endometriosis
Potential of Cannabinoids for the Treatment of Endometriosis
https://www.cientperiodique.com/article_in_press/CPQME-101.pdf
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Timeline of research
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2024: In endometrial cells, the regulation effects of the endocannabinoid system & the effects on the menstrual cycle & endometriosis
Endometrial Cell-Type Specific Regulation of the Endocannabinoids System and the Impact of Menstrual Cycle and Endometriosis
https://pubmed.ncbi.nlm.nih.gov/39286880/
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2024: In a mouse model of endometriosis, an analysis of the endocannabinoid system’s involvement in disease progression & immune response
Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response
https://www.proquest.com/openview/1c2c6050085871f6ec0effdc9d8a9d22/1
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2023: In a rat model of endometriosis, CBD caused significant anti-inflammatory & antioxidative effects
Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and antiangiogenic effects in an experimental rat model
https://pubmed.ncbi.nlm.nih.gov/36997400/
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2022: In a model of endometriosis, CBD reduced lesions, caused antioxidant effects, lowered scar tissue formation, reduced inflammation & helped with pain
Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis
https://pubmed.ncbi.nlm.nih.gov/35628240
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2021: In a mouse & tissue model of endometriosis, an activator of the CB1 receptor reduced cell proliferation, blood vessel growth & reduced pain stimuli
Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis
https://pubmed.ncbi.nlm.nih.gov/36304004
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2020: In a mouse model endometriosis, THC lessened their pain & mechanical hypersensitivity, modified their uterine innervation & restored cognitive function
Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
https://pubmed.ncbi.nlm.nih.gov/31931958/
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2016: In rats with endometriosis, ultramicronized PEA lowered pain, cysts, and stones (includes comment & reply) via the mast cells
Ultramicronized Palmitoylethanolamide Reduces Viscerovisceral Hyperalgesia in a Rat Model of Endometriosis Plus Ureteral Calculosis: Role of Mast Cells
https://pubmed.ncbi.nlm.nih.gov/25974242/
2012: How THC effects GPR18 & endometriosis
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells
https://www.ncbi.nlm.nih.gov/pubmed/21595653
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