Research Roundup: Apr 1, 2025
- Lex Pelger
- Apr 1
- 4 min read
Best of cannabinoid science this week...
In a double-blind trial of people with insomnia, a soft gel with THC, CBN, CBD & a terpene blend significantly improved sleep quality/efficacy, insomnia symptoms & health-related quality of life
Effectiveness of a Cannabinoids Supplement on Sleep and Mood in Adults With Subthreshold Insomnia: A Randomized Double-Blind Placebo-Controlled Crossover Pilot Trial
And in veterans, cannabis use was linked to reduced stress & better same-night sleep quality
Daily associations between sleep quality, stress, and cannabis or alcohol use among veterans
In Thai palliative cancer patients taking cannabis vs. morphine, the cannabis using group lived longer, had a lower hospital admission rate, had fewer hospital days & a better quality of life
Survival Rates, Quality of Life and Side Effects of Medical Cannabis in Patients with Palliative Cancer in Thailand
In people with rheumatoid arthritis, public health data showed cannabis users had lower mortality, depression, chronic pain & anxiety but higher risks of opioid, nicotine & alcohol use
Inpatient outcomes of rheumatoid arthritis in hospitalized patients using cannabis: data from the National Inpatient Sample
In people with moderate to severe atopic dermatitis (red itchy skin), a 2% CBD topical cream caused improvements in skin hydration, comfort, inflammation relief & overall skin appearance
Improvement in Atopic Dermatitis Using a Novel Topical 2% Cannabidiol (CBD) Application
In people with alcohol use disorder, a full-spectrum CBD product lowered cravings more than a placebo or a broad-spectrum CBD product
A Preliminary Randomized Trial of the Safety, Tolerability, and Clinical Effects of Hemp-Derived Cannabidiol in Alcohol Use Disorder
For a range of rare genetic epilepsies, on the efficacy of CBD
Expanding the therapeutic role of highly purified cannabidiol in monogenic epilepsies: A multicenter real-world study
In people with migraines, the combination of PEA & melatonin significantly reduced migraine frequency
Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial
For headaches & migraines, a review of using the cannabinoids
Cannabinoids in headache: helpful or harmful?
For mucosal lesions (a common side effect of chemotherapy & a symptom of burning mouth syndrome), a systematic review of seven studies found CBD to reduce inflammation, lower pain & heal lesions
The therapeutic effect of cannabidiol in oral mucosa lesions:
For cancer-related pain, a review of nano delivery systems of CBD
Cannabidiol from Conventional to Advanced Nanomedicines for the Management of Cancer-Associated Pain
For inflammatory bowel disease symptoms outside the intestines, a review of targeting the endocannabinoid system (good charts)
Targeting the Endocannabinoidome: A Novel Approach to Managing Extraintestinal Complications in Inflammatory Bowel Disease
For glaucoma, a review of the potential of cannabinoid drugs & the involvement of the endocannabinoid system
Role of Endocannabinoids in Glaucoma: A Review
And a review on cannabinoids as multidrug targets for treating autoimmunity in glaucoma
Cannabinoids as Multitarget Drugs for the Treatment of Autoimmunity in Glaucoma
For fibromyalgia, a review of the role of the endocannabinoid system
Role of the Endocannabinoid System in Fibromyalgia
For dentistry & oral diseases, a review of using cannabis
Multipurpose Implications of Medicinal Cannabis and Related Drugs in D…
In a rat model of spinal cord injury, a cannabis extract improved locomotor recovery, enhanced the anti-inflammatory response, prevented secondary damage, reduced the number of neurotoxic astrocytes (the most predominant brain support cell) & decreased inflammatory microglia (guardian immune cells of the brain)
Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinfalmmation and improves locomotor outcome following spinal cord injury
In a rat model of diabetes, CBD lowered blood glucose & increases insulin as well as other anti-diabetic effects
Unlocking the Antidiabetic Potential of CBD: In Vivo Preclinical Studies
In a rat model of schizophrenia induced by ketamine, CBD improved behaviors & improved oxidative stress & neuroinflammation
Cannabidiol reverses myeloperoxidase hyperactivity in the prefrontal cortex and striatum, and reduces protein carbonyls in the hippocampus in a ketamine-induced schizophrenia rat model
In a mouse model of blood loss to the brain, CBG lessened the memory deficits, reduced neuronal loss in the hippocampus (memory center of the brain) & enhanced neuronal plasticity
Cannabigerol Attenuates Memory Impairments, Neurodegeneration, and Neuroinflammation Caused by Transient Global Cerebral Ischemia in Mice[v1]
In a rat model of diabetic kidney disease & inflammation from a high-fat high-sucrose diet, CBG reduced biomarkers of kidney damage & had potential anti-inflammatory properties
The Identification of Novel Anti-Inflammatory Effects of Cannabigerol in the Kidney Tissue of Rats Subjected to a High-Fat High-Sucrose Diet
Against the drug-resistant bacteria Streptococcus iniae, CBG inhibited growth & biofilm formation via DNA leakage, impaired cell membrane integrity, hyperpolarized membrane potential & reduced respiratory chain activity
Evaluation of the antibacterial activity and mechanism of cannabigerol against drug-resistant Streptococcus iniae in vitro
In a tissue model of Alzheimer's disease, CBN caused neuroprotection via genetic regulation of mRNA splicing
Cannabinerol Restores mRNA Splicing Defects Induced by β-Amyloid in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study
In a model of neuroinflammation using microglia (guardian immune cells of the brain), CBD as well as full-spectrum THC extracts lowered neuroinflammatory markers with comparable or superior efficacy to the common treatment of dexamethasone sodium phosphate
Assessing neuroinflammation in vitro in a microglial model: advancing cannabinoid-based therapeutic insights
In a mouse model of stroke, the terpene β-caryophyllene alleviated brain damage, inhibited neuronal death & lowered the inflammatory response via suppression of HMGB1/TLR4/RAGE signaling & reducing the expression of IL-1β/IL-6/TNF-α
β-caryophyllene reduces inflammation to protect against ischemic stroke by suppressing HMGB1 signaling
In a rat model of Fragile X Syndrome (a genetic disorder of intellectual disability & a wide range of comorbidities), the terpene beta-carophyllene rescued cognitive deficits via PPAR nuclear receptors (regulators of genetic transcription) in the hippocampus (memory center of the brain)
Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome
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