Research Roundup: Apr 8, 2025
- Lex Pelger
- Apr 8
- 2 min read
Best of cannabinoid science this week...
In Australians prescribed medical cannabis, real-world health data showed clinically meaningful improvements in fatigue, anxiety, depression, sleep & health-related quality of life that were maintained over 12 months
Improvements in health-related quality of life are maintained long-term in patients prescribed medicinal cannabis in Australia: The QUEST Initiative 12-month follow-up observational study
In a pediatric cannabis clinic, characterizing the population
Characterizing the Population of a Medical Cannabis Clinic in a Pediatric Hospital
For mental health, a review of 49 studies using cannabinoids
The differential effects of medicinal cannabis on mental health: A systematic review
For the pain of cancer patients, a review of 33 papers on the efficacy of the cannabinoids
Cannabinoids: Do they alleviate pain in cancer patients?
For chronic pain, review of 60 trials on using CBD, especially in combination with PEA
Considering Long-Acting Synthetic Cannabidiol for Chronic Pain: A Narrative Review
And for chronic nerve pain, a review of the cannabinoids
EFFICACY AND SAFETY OF CANNABINOIDS IN PATIENTS WITH NEUROPATHIC PAIN (LITERATURE REVIEW)
For asthma, a review on the potential synergies between cannabinoids & common inhaler treatments
Is There a Place for Cannabinoids in Asthma Treatment?
In Siamese fighting fish, CBD reduced their aggressive behavior
Cannabidiol on aggression in betta fish (Betta splendens)
I just hope it works on my ex-wife…
In a rat model of eye injury due to blood loss, CBD incorporated into niosomes (non-ionic vesicles for drug delivery) injected into the eye preserved retinal structure & function
Intravitreal CBD-loaded niosomes enhance retinal neuroprotection in ischemic injury
In a mouse model of autism, CBD improved their repetitive behaviors & social interaction deficits & reversed dysregulation of neurons producing GABA (the brain’s primary inhibitory neurotransmitter)
Cannabidiol alleviates valproic acid-induced developmental changes in mice pups: role of the allosteric modulation of the CB1 receptor in the regulation of the GABAergic system
In a rat model of Parkinson's, both CBD pre-administration & CBD treatment reduced motor alterations & lessened catalepsy
Preventive Beneficial Effects of Cannabidiol in a Reserpine-Induced Progressive Model of Parkinsonism
In a rat model of neuropathy from chemotherapy (paclitaxel), early oral administration of both a formulation of THC:CBD 1:20 as well as a 1:1 prevented pain hypersensitivities & the 1:1 restored spontaneous activities
Early oral administration of THC:CBD formulations prevent pain-related behaviors without exacerbating paclitaxel-induced changes in weight, locomotion, and anxiety in a rat model of chemotherapy-induced neuropathy
In mouse models of seizures, treatments with CBD/THC and/or CBD reduced seizures, oxidative stress & astrogliosis (an abnormal increase in astrocytes, the brain's primary support cells)
Nanoemulsions of Cannabidiol, Δ9-Tetrahydrocannabinol, and Their Combination Similarly Exerted Anticonvulsant and Antioxidant Effects in Mice Treated with Pentyelenetetrazole
In intestinal tissue, CBD reduced inflammation & strengthened the epithelial barrier of Peyer’s Patches (lymph nodules in the intestinal wall)
Barrier-Strengthening Effects of Cannabidiol on Porcine Peyer’s Patches
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