Best of cannabinoid science this week...
In older adults, an assessment of medical cannabis use found a decline in all symptoms including negative affect, pain & nausea
Effects of medical cannabis use on physical and psychiatric symptoms across the day among older adults
In people with anxiety, they reported CBD helped the most with subjective anxiety, difficulty falling asleep & irritability
Cannabidiol (CBD) Products: Use Patterns and Perceptions Within a Sample of Anxious Users
In people with chronic musculoskeletal pain, a survey found that the majority of cannabis users found it to be “very” or “somewhat effective” for pain
Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain
In a case report of neuropathic pain from chemotherapy treatment, CBD & exercise improved pain symptoms, mobility, hand & finger dexterity, upper & lower body strength, beneficial gut bacteria & quality of life
Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report
In a double-blind placebo trial of hemp-derived CBD in healthy adults, those taking the CBD had lower pain scores
The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical trial
In adults with Lennox-Gastaut syndrome (a childhood-onset epilepsy), CBD as an add-on treatment reduced the frequency of both focal & generalized seizures & was well tolerated with 94% of the cohort continuing on the drug
Is adjunctive Cannabidiol effective in controlling seizures for adult patients with Lennox-Gastaut Syndrome? - A single centre long term follow up study
And in two case reports of difficult-to-treat status epilepticus (seizures that last more than 5 minutes), treatment with CBD via a gastric tube reduced seizures
Effectiveness of Highly Purified Cannabidiol in Refractory and Super-Refractory Status Epilepticus: A Case Series
In neurodegenerative disease, a review of how cannabinoids modulate the immune system (with nice charts!)
Cannabinoids' Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases
For postoperative pain, a review of using cannabinoids for analgesia (with nice charts!)
Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality
For strokes, a review on the therapeutic potential of using CBD (with nice charts!)
Potential of CBD Acting on Cannabinoid Receptors CB1 and CB2 in Ischemic Stroke
A review of the anti-cancer properties of CBD (with nice charts!)
Anti-Cancer and Anti-Proliferative Potential of Cannabidiol: A Cellular and Molecular Perspective
For acute inflammatory pain, a review of using transdermal CBD (with nice ECS skin charts!)
Transdermal Delivery of Cannabidiol for the Management of Acute Inflammatory Pain: A Comprehensive Review of the Literature
For gut health, a review of how cannabinoids alter intestinal motility, barrier permeability & a look at their therapeutic potential (with nice charts!)
Effects of Cannabinoids on Intestinal Motility, Barrier Permeability, and Therapeutic Potential in Gastrointestinal Diseases
For chronic pain, a review of using PEA
Practical update on oral palmythopylethanolamide (PEAum) in the management of chronic pain. Narrative review
For neurological diseases, a book chapter on the use of cannabinoids
Cannabis Compounds: Potential Therapy for Neurological Disease
And for neurodegenerative disorders, on the synergistic therapeutic benefits of CBD with vitamin B12
Cannabinoids: Potential for Modulation and Enhancement When Combined with Vitamin B12 in Case of Neurodegenerative Disorders
For anxiety, a meta-analysis of eight studies showed CBD to have a considerable effect size
Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis
And a review on whether the serotonin & BDNF-TrkB signaling systems mediate CBD's antidepressant effects
New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect
For multiple sclerosis, a review of using the cannabinoids
Exploring the efficacy of cannabinoids in the management of multiple sclerosis
In a skin stem cell model of acne & acne scarring, CBD “remarkably” reduced pro-inflammatory cytokines, increased the levels of elastin & collagens, inhibited lipid synthesis & promoted apoptosis (programmed cellular suicide close parents among damaged cells
Potential of cannabidiol as acne and acne scar treatment: novel insights into molecular pathways of pathophysiological factors
In a mouse model of memory loss induced by scopolamine, CBD protected from the memory loss & produced synergistic protection effects when combined with rivastigmine (a cholinesterase inhibitor used to treat mild Alzheimer's disease)
The Influence of an Acute Administration of Cannabidiol or Rivastigmine, Alone and in Combination, on Scopolamine-Provoked Memory Impairment in the Passive Avoidance Test in Mice
In obese mice, the weight reductions caused by THC can be predicted by the variations it causes in the microbiome
Microbiome Variations Induced by delta9-Tetrahydrocannabinol (THC) Predicts Weight Reduction in Obese Mice
In a model of colitis, CBD reduced intestinal damage & cell death
Cannabidiol decreases histological intestinal injury in a neonatal experimental model of necrotizing enterocolitis
In a tissue model of atherosclerosis (hardened arteries), CBD modulated cholesterol levels in the macrophages (immune cells) via ceramide levels & ABCA1 & ABCG1 expression controlled by the nuclear PPAR receptors (regulators of genetic expression)
Cannabidiol (CBD) Inhibits Foam Cell Formation via Regulating Cholesterol Homeostasis and Lipid Metabolism
In a rat model of heart damage from cancer treatment, CBD oil lowered cardiac enzymes & inflammatory markers as well as acting as an antioxidant
Eventual Medicinal Benefits of Cannabidiol Oil alleviates Doxorubicin Related Cardiac injuries
In a model of Alzheimer's disease, CBN prevented dysfunctions of the mitochondria & endoplasmic reticulum (protein transportation & folding center)
Cannabinerol Prevents Endoplasmic Reticulum and Mitochondria Dysfunctions in an In Vitro Model of Alzheimer's Disease: A Network-Based Transcriptomic Analysis
In mice, cannabis extracts caused antidepressant & anti-inflammatory effects
In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of Cannabis sativa L. Extracts
In a tissue model of gastrointestinal inflammation, CBD, CBDV & CBG protected against increases in permeability
Selected phytocannabinoids inhibit SN-38- and cytokine-evoked increases in epithelial permeability and improve intestinal barrier function in vitro
In skin stem cells exposed to UVB, a full-spectrum CBD topical reduced cell death & inhibited inflammatory markers
Full-spectrum cannabidiol reduces UVB damage through the inhibition of TGF-β1 and the NLRP3 inflammasome
And in skin cells & skin stem cells, topical CBD & CBG reduced UVA radiation’s inflammation & oxidation effects
Modulation of Redox and Inflammatory Signaling in Human Skin Cells Using Phytocannabinoids Applied after UVA Irradiation: In Vitro Studies
In a rat model of high blood pressure in the lungs, a pharmaceutical CBD drug significantly reduced pulmonary arterial pressure & hypertrophy of the right ventricles as well as reversing pulmonary vascular remodeling via the reduction of pyroptosis (inflammatory cell death) using inhibition of the NF-κB/NLRP3/Caspase-1 pathway
DYZY01 alleviates pulmonary hypertension via inhibiting endothelial cell pyroptosis and rescuing endothelial dysfunction
Another toxicity analysis of CBD found it to be non-mutagenic & non-genotoxic
Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from Cannabis sativa L
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