Best of cannabinoid science this week...
In a survey of people with end-stage cancer, the majority reported cannabis to have a symptom-relieving effect
Perception and Consumption of Cannabis Among Danish Patients with End-Stage Cancer Receiving Palliative Care: A Cross-Sectional Survey
In interviews of professional athletes, they used cannabis orally, by inhalation & topically & their reasons for use included relaxation, physical discomfort, mental health, recreation & cerebral effects
Athletes’ and Retired Athletes’ Experiences with and Perspectives on Cannabinoids
For pain from nail-patella syndrome (a rare genetic disease of skeletal malformation), three months of CBD caused a significant reduction in pain intensity as well as improvements to health-related quality of life & other syndrome symptoms
Evidence for therapeutic use of cannabidiol for nail-patella syndrome-induced pain in a real-world pilot study
For HIV & cancer, a review of 51 studies on using cannabis for symptom management
A Scoping Review of Observational Research on Cannabis Use for Symptom Management in HIV and Cancer: Implications for Cannabis Nursing
For the immune system, a review of the complex immunomodulation by the endocannabinoid system
Immunomodulation via the Endocannabinoid System: Mechanisms and Therapeutic Potentials
In a rat model of autism, CBD combined well with risperidone for significantly improving their sociability
Effects of Cannabidiol Isolated or in Association With Risperidone in an Animal Model of Autism
In a rat model of liver injury from chemotherapy treatment, CBD mitigated liver toxicity & damage via reductions to oxidative stress, inflammation & apoptosis (programmed cellular suicide) via the genetic regulation of p53, Bcl-2 & Bax
Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1/p53 signaling and mitochondrial pathways: reduces oxidative stress and inflammation
In a rat model of systemic inflammation during pregnancy, prenatal CBD usage suppressed the offspring’s neuroinflammation & protected neurogenesis (birth of new brain cells)
Evaluation of Cytoprotective Effects of Cannabidiol on Neuroinflammation and Neurogenesis Process in Rat Offsprings
And in a mouse model of autism from prenatal exposure to valproic acid, administration of CBD to the adults lowered their behavioral impairments
Acute cannabidiol treatment reverses behavioral impairments induced by embryonic valproic acid exposure in male mice
In horse fat stem cells, a CBD-rich extract modulated the expression of pro- & anti-inflammatory cytokines
In Vitro Immunomodulatory Effects of Equine Adipose Tissue-Derived Mesenchymal Stem Cells Primed with a Cannabidiol-Rich Extract
How do cannabinoids bind to the GABA receptor?
Structure and dynamics of cannabinoid binding to the GABAA receptor
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