Best of cannabinoid science this week...
In people with PTSD, inhalation of THC improved overall health, mood & sleep quality as well as benefits for managing intrusion symptoms, mood alterations & reactivity alterations
Controlled Inhalation of Tetrahydrocannabinol-Predominant Cannabis Flos Mitigates Severity of Post-Traumatic Stress Disorder Symptoms and Improves Quality of Sleep and General Mood in Cannabis-Experienced UK Civilians: A Real-World, Observational Study
For rare childhood epilepsies, a cost-utility analysis found CBD plus usual care found an increased quality of life & a cost saving of €23,642
Cost-Utility Analysis of Add-on Cannabidiol vs Usual Care Alone for the Treatment of Seizures in Patients With Treatment-Resistant Lennox-Gastaut Syndrome or Dravet Syndrome in the Netherlands
For PEA, a review of 47 randomized control trials showcased the efficacy on pain management, general well-being & the modulation of immune biomarkers
Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populations
And for neuropathic pain, a review of PEA (nice graphical abstract)
Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic pain
For neuropathic pain, a review of five studies found cannabinoids to provide significant relief from chronic pain
Cannabinoids as a Natural Alternative for the Management of Neuropathic Pain: A Systematic Review of Randomized Placebo-Controlled Trials
For athletic endurance & performance, a review on the potential of cannabinoids for managing chronic pain, inflammation, neurological conditions & injury recovery as well as a replacement for opioids for pain relief
The impact of cannabis on endurance and performance of athletes - risks and benefits - a literature review
On the endocrine system, a review of the effects of cannabinoids on hormones, food intake, glycemia regulation, oxytocin & reproduction
The Effects of Cannabinoid Compounds on the Endocrine System
For neurological & psychiatric disorders, a review of the cannabinoids
Cannabinoids: Role in Neurological Diseases and Psychiatric Disorders
In a rat model of neuropathic pain, PEA increased the painkilling effects of tramadol & reduced its adverse effects with the combination of tramadol & PEA at low doses being as effective as tramadol alone at high doses
N-Palmitoylethanolamide enhances antinociceptive effect of tramadol in neuropathic rats
In a rat model of Alzheimer's disease, both CBD & CBG enhanced their learning & memory functions & reduced the levels of inflammatory cytokines
Cannabidiol and cannabigerol effect on cognitive deficit induced by intracerebroventricular administration of amyloid beta 42 in experimental Alzheimer's disease model
In socially isolated male mice, CBD reduced their depressive symptoms but “unexpectedly induced anxiety-like behavior in group-housed mice”
Chronic cannabidiol administration modulates depressive and cognitive alterations induced by social isolation in male mice
In the skeletal muscle of rats, THC aggravated the alcohol-related impairment of the mitochondria (powerhouse of the cell)
Cannabis (THC) Aggravates the Deleterious Effects of Alcohol (EtOH) on Skeletal Muscles’ Mitochondrial Respiration: Modulation by Age and Metabolic Phenotypes
In a rat model of ulcerative colitis, cannabis significantly improved colonic architectural abnormalities, suppressed pro-inflammatory cytokines & upregulated CB1 & SIRT levels in the colon
Cannabis sativa alleviates experimentally acetic acid-induced ulcerative colitis in rats
In a rat model of fragile X syndrome (a genetic neurodevelopmental disease), the terpene beta-caryophyllene improved cognition not via the CB2 receptors but via the PPAR nuclear receptors (that regulate genetic transcription) in the hippocampus (memory center of the brain)
Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome
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