Best of cannabinoid science this week...
In a sleep diary study, cannabis use was associated with improved sleep quality Cannabis use and sleep quality in daily life: An electronic daily diary study of adults starting cannabis for health concerns https://pubmed.ncbi.nlm.nih.gov/36638745/
In mice with high blood pressure, one month of cannabis oil reduced their hypertension & improved their network of mitochondria (powerhouse of the cell) probably via its antioxidant effects Cannabis oil one-month oral treatment given to spontaneously hypertensive rats (SHR): Could it be a promising therapeutic strategy for hypertensive cardiac hypertrophy? https://www.sciencedirect.com/science/article/pii/S0022282822003959
CBD is protective of the heart in several diseases via its antioxidant & cardioprotective effects Treatment with Cannabidiol Results in an Antioxidant and Cardioprotective Effect in Several Pathophysiologies https://pubmed.ncbi.nlm.nih.gov/36508270/
In a rat model of obesity, CBD rich hemp extracts protected the heart via the inhibition of the transport of adenosine (a messenger of protein synthesis) The effect of a long-term treatment with cannabidiol-rich hemp extract oil on the adenosinergic system of the zucker diabetic fatty (ZDF) rat atrium https://pubmed.ncbi.nlm.nih.gov/36588715/
In a mouse model of nerve pain, CBD-rich extract lowered their pain sensitivity via the CB2 receptors of the microglia (immune guardian cells of the brain) Cannabidiol-rich non-psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2-mediated microglial neuroinflammation https://pubmed.ncbi.nlm.nih.gov/36583304/
In skin connective tissue, both THC & CBD decreased aging & improved wound healing more effectively than the top skin ingredients they were tested against Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts https://pubmed.ncbi.nlm.nih.gov/36497198/
A review of the effects of using cannabinoids for Parkinson's disease in animal models
Effects of cannabinoids in Parkinson's disease animal models: a systematic review and meta-analysis
In a roundworm model of Parkinson’s disease, CBDV lowered the aggregation of the α-synuclein plaques as well as oxidative stress & the death of dopamine producing neurons Cannabidivarin alleviates α-synuclein aggregation via DAF-16 in Caenorhabditis elegans https://pubmed.ncbi.nlm.nih.gov/36583706/
In a review of seven clinical trials on patients with MS, the use of Sativex (a 1:1 CBD: THC spray) caused no detrimental effects on cognitive function after 12 months of use Effects of SativexⓇ on cognitive function in patients with multiple sclerosis: A systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/36174323/
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