Best of cannabinoid science this week...
On inflammatory bowel disease, the UK Medical Cannabis Registry found cannabis improved sleep, anxiety, disease symptoms & patient-reported outcomes
UK medical cannabis registry: an updated analysis of clinical outcomes of cannabis-based medicinal products for inflammatory bowel disease
In people with acute alcohol use disorder, 800 milligrams of CBD significantly lowered their alcohol craving & fMRI showed less cue-induced activation of the nucleus accumbens (a brain region related to addiction, motivation & reward)
Acute cannabidiol administration reduces alcohol craving and cue-induced nucleus accumbens activation in individuals with alcohol use disorder: the double-blind randomized controlled ICONIC trial
In women with breast cancer who are anxious about their scans to assess tumor burden, 400 milligrams of CBD before the scan led to significantly lower anxiety levels
Cannabidiol for Scan-Related Anxiety in Women With Advanced Breast Cancer A Randomized Clinical Trial
In a survey of people with upper-extremity pain, a survey found that 40% used cannabis as part of their treatment & 47% were OK with their doctor using cannabis outside of work (compared to 64% comfortable with their use of alcohol outside of work)
Perceptions of Patient and Surgeon Marijuana Use: A Survey Study of Upper-Extremity Patients
In a case series of children with severe neurodisabilities & related gastrointestinal problems, treatment with nabilone (a synthetic derivative of THC) improved scores on their pediatric quality of life inventory (PedsQL)
Nabilone for the treatment of gastrointestinal dystonia for children and young people with severe neurodisabilities: a single-centre case series
“In particular, symptoms of nausea, retching and pain on feeding were all reduced in our cohort.”
In an elderly person, two months of oral cannabis led to substantial & rapid weight loss
A rapid weight loss caused by therapeutic cannabinoid use in an elderly individual: a case report
In a case report of a rare refractory epilepsy due to creatine transporter deficiency, CBD & clobazam reduced ~10-20 focal motor seizures per month down to zero for the first year as well as behavioral improvements
Successful management of refractory epilepsy in creatine transporter deficiency with cannabidiol and clobazam: A case report
In a 2-year-old Yorkshire terrier, treating their chronic inflammatory enteropathy (intestinal problems) with budesonide, CBD oil & probiotics
SUCCESSFUL TREATMENT OF CHRONIC INFLAMMATORY ENTEROPATHY IN 2-YEAR-OLD YORKSHIRE TERIER. CASE REPORT
In treating youth psychiatric disorders with cannabinoids, a review of eight trials showed a modest positive effect for symptom improvement with the most consistent evidence for autism
Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials
In cancer patients using cannabis products, this review of 152 studies found they were used most to manage nausea, vomiting & cancer pain with the primary routes of administration being oral or inhalation
Adverse events associated with the use of cannabis-based products in people living with cancer: a systematic scoping review
On the gut microbiome, a review of the effects of medical cannabis including a great table of all the studies
Medicinal Cannabis and the Intestinal Microbiome
And for the microbiome, a comprehensive review of the interactions with the cannabinoids
Cannabis and cannabinoid-microbiome interactions in varied clinical contexts: A comprehensive systematic review
On bariatric surgery, an even-handed review of the effects of cannabis use before & after the surgery
Cannabis use before and after metabolic and bariatric surgery: literature review
For Parkinson's disease, a review of using the cannabinoids (some good charts)
Cannabinoids and its disease targeting mechanisms for Parkinson's Disease and Cancer
For stem cells, a review of 27 papers on the effects of CBD highlighted its protective abilities & influence over differentiation
Cannabidiol effects in stem cells: A systematic review
In a rat model of neuropathic pain, CBD caused neuroplasticity via the kappa opioid receptor
Acute Kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats
And in a mouse model of postoperative pain & fibromyalgia, the terpenes geraniol, linalool, β-caryophyllene & α-humulene cause pain killing effects via the adenosine receptors
Select terpenes from Cannabis sativa are antinociceptive in mouse models of post-operative pain and fibromyalgia via adenosine A2a receptors
And in a rat model of pain, the combination of CBD-rich cannabis oil & oil of Bixa orellana (the achiote shrub of Central America) caused significant pain reduction
Synergistic Pain-Reducing Effects of Bixa orellana (Chronic® and Chronic In®) and Cannabidiol-Rich Cannabis sativa Extracts in Experimental Pain Models
In a mouse model of papillomavirus (in humans, HPV), moderate doses of CBD & THC significantly reduced viral DNA in the blood of males but marginally increased the viral RNA levels on their tongue (with opposite effects on the females), suggesting cannabinoids promoting persistence of the virus in the oral cavity
Intraperitoneal delivery of cannabidiol (CBD) and Δ9-tetrahydocannabinol (THC) promotes papillomavirus infections in athymic nude mice
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