Research Roundup: Mar 18, 2025
- Lex Pelger
- Mar 18
- 3 min read
Best of cannabinoid science this week...
For chronic pain, a comparison of medical cannabis vs conventional prescription treatments found the cannabis to be more effective by an odds ratio of 2.6
The comparative effectiveness of medicinal cannabis for chronic pain versus prescription medication treatment
On hypermobility-related chronic pain, the UK Medical Cannabis Registry showed that beginning treatment with cannabis-based medical products improved pain, sleep, anxiety & health-related quality of life
UK Medical Cannabis Registry: An Analysis of Outcomes of Medical Cannabis Therapy for Hypermobility-Associated Chronic Pain
For children with rare childhood epilepsies, CBD reduced total seizures & 70% were still using it a year later
Real-world experience of cannabidiol in conjunction with clobazam for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome
For autism, two case reports where PEA improved language, sociability, behaviors & cognition
Beneficial Effects of Palmitoylethanolamide on Expressive Language, Cognition, and Behaviors in Autism: A Report of Two Cases
In people with radiation treatment for head & neck cancer, CBD alone & when combined with photobiomodulation (laser light therapy) lowered mucositis (inflammation of oral & GI mucous membranes)
Cannabinoids as a therapeutic option for controlling radio-induced oral mucositis in patients with head and neck cancer
In dogs who had their ovaries removed, CBD helped with the pain, especially in combination with the NSAID meloxicam
Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia
For chronic pain, a review of using cannabis
Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review
For metabolic disorders & diabetes, a review of THCV
The role of tetrahydrocannabivarin (THCV) in metabolic disorders: A promising cannabinoid for diabetes and weight management
In HIV & SIV (the ape version), a review of 19 studies of the effects of THC on the immune system as a potential complementary therapy
Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
For cannabis use disorder, a systematic review of using cannabinoids as a treatment, especially CBD & nabiximols (a 1:1 THC:CBD spray)
Assessing the efficacy of cannabinoids in managing cannabis use disorder: A systematic review of randomized controlled trials with pharmacological emphasis
On the gut microbiome, a review of its symphony with the endocannabinoid system
Symphony of the Gut Microbiota and Endocannabinoidome: A Molecular and Functional Perspective
For CBG & heart health, a review of its potential
Comprehensive Mini-Review: Therapeutic Potential of Cannabigerol -Focus on Cardiovascular System
In a mouse model of sickle cell disease, PEA reduced hypersensitivity to pain, spinal inflammation & oxidative stress
Neuroprotective, anti-inflammatory and analgesic activity of palmitoylethanolamide in sickle cell mice
In a rat model of depression, CBD improved symptoms & altered a host of endocannabinoid & transcriptional machinery with gendered effects
Cannabidiol Modulates Neuroinflammatory and Estrogen-Related Pathways in a Sex-Specific Manner in a Chronic Stress Model of Depression
In a rat model of exhaustive exercise, CBD reduced inflammation & genetic expression of the tumor necrosis factor signaling pathway & the Toll-like receptor signaling pathway
Mining and verification of inflammation-related genes in skeletal muscle of exhaustive exercise rats undergoing cannabidiol intervention
In rats with high levels of insulin in their blood, THC protected their hearts against oxidative stress, inflammation & apoptosis (programmed cellular suicide)
Δ(9)-tetrahydrocannabinol protects cardiac tissue against endoplasmic reticulum and oxidative stresses, apoptosis, and inflammation in rats with hyperinsulinemia
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