Research Roundup: Mar 25, 2025
- Lex Pelger
- Mar 18
- 2 min read
Best of cannabinoid science this week...
For people with multiple sclerosis, vaporized cannabis improved all of their measurements including muscle spasticity, bladder function & disability progression rate
Evaluating Vaporized Cannabinoid Therapy in Multiple Sclerosis: Findings from a Prospective Single-Center Clinical Study
In people with treatment-resistant epilepsy, a meta-analysis of six studies found CBD reduced total seizures by 41% with a response rate of 127%
The efficacy of cannabidiol for seizures reduction in pharmacoresistant epilepsy: a systematic review and meta-analysis
In people with atopic dermatitis (red itchy skin), an ointment of 30% CBD, 5% CBG & hemp seed oil improved redness, itchiness, skin hydration & sebum levels
Evaluation of Biophysical Parameters of the Skin of Patients With Atopic Dermatitis After Application of an Ointment Containing 30% Cannabidiol and 5% Cannabigerol
In people with alcohol use disorder, CBD lowered their brain activation to alcohol cues
Cannabidiol attenuates precuneus activation during appetitive cue exposure in individuals with alcohol use disorder
For autism, a review of seven studies found CBD-rich formulations to help with sleep, social interactions & anxiety symptoms
Efficacy and Safety of Cannabinoids for Autism Spectrum Disorder: An Updated Systematic Review
On cannabis for opioid use disorder, a review of its opioid-sparing effects to reduce opioid use in pain management
Medicine vs. Myth: Exploring the Therapeutic Potential of Cannabis for Opioid Use Disorder and Pain
On neurodegenerative diseases, a review of cannabinoids & neuroprotection (one good chart)
Multilayered neuroprotection by cannabinoids in neurodegenerative diseases
In pediatric epilepsy, a review of using the cannabinoids
Cannabinoid Use in Pediatric Epilepsy
For the pain of rheumatic diseases, on the possibility of cannabis as an opioid alternative
Cannabis: an opioid alternative for pain management in rheumatic diseases?
In a mouse model of neuropathic pain, CBD restored memory deficits & caused potent antiallodynic effects (hypersensitivity to innocuous touch) via spinal cord receptors for serotonin & PPAR (regulator of genetic transcription)
Cannabidiol reduces neuropathic pain and cognitive impairments through activation of spinal PPARγ
And in a mouse model of neuropathic pain, terpene blends from cannabis mimicked the pain-killing effects of cannabis via adenosine receptors
Terpene blends from Cannabis sativa are cannabimimetic and antinociceptive in a mouse chronic neuropathic pain model via activation of adenosine A2a receptors
In a mouse model of epilepsy, CBD reduced neuronal loss, lessened seizures, enhanced memory capabilities, & suppressed the formation of neurotoxic reactive astrocytes (the most predominant brain support cell)
Cannabidiol Protects Against Neurotoxic Reactive Astrocytes‐Induced Neuronal Death in Mouse Model of Epilepsy
In mice with neuroinflammation from sleep deprivation, CBD, CBG & CBC all lowered the behavioral & neuroinflammatory changes, but the most effective was CBD + CBC
Long-term Cannabinoid Therapy can ameliorate Sleep Deprivation-Induced Behavioral and Neuroinflammatory Changes in Mice
In rats on a high-calorie diet, CBD lessened the changes to the pancreatic islets & modified body weight & food intake without changes to blood glucose or insulin
Cannabidiol oil delays pancreatic islet dysfunction in Wistar rats under hypercaloric diet
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